188体育

188体育-www.bncc.org.cn北纳生物

揭示洛伐他汀水解酶催化机制

发布时间:2020-02-17 13:17 作者:潘东
0

GAOXUEZHIZHENGSHIZHIXUEYEZHONGDANGUCHUN、GANYOUSANZHIDENGZHILEIWUZHIYICHANGSHENGGAO,KEZHIJIEYINQIYIXIEYANZHONGWEIHAIRENTIJIANKANGDEJIBING,TONGGUOJIANGDANGUCHUNYAOWUDIAOJIEXUEZHISHIMUQIANYUFANGHEZHILIAOGAOXUEZHIZHENGDEYOUXIAOFANGFA。XINFATATING(Zocor)SHIYIZHONGZHONGYAODEJIANGDANGUCHUNYAOWU,QIGONGYESHENGCHANBAOKUOSANGEBUZHOU:TUQUMEIFAJIAOSHENGCHANLUOFATATING,JIANSHUIJIELUOFATATINGZHIBEIZHONGJIANTImonacolin J,HUAXUEHUOSHENGWUFANGFAJIANGmonacolin JZHUANHUAWEIXINFATATING。DANCHUANTONGJIANSHUIJIESHENGCHANmonacolin JGONGXUXIANGDUIFUZA、CHENGBENANGGUIQIEHUANJINGWURANJIAODA。SHIYONGTEYIQIEGAOXIAODELUOFATATINGSHUIJIEMEIJINXINGMEICUHECHENGSHILVSESHENGCHANmonacolin JDEKETIDAIFANGFAZHIYI。

ZHONGGUOKEXUEYUANQINGDAOSHENGWUNENGYUANYUGUOCHENGYANJIUSUOYANJIUYUANLVXUEFENGDAILINGDEWEISHENGWUDAIXIEGONGCHENGYANJIUZUZHILIYUTATINGLEIJIANGXUEZHIYAOWUDESHENGWUHECHENGYANJIU(Metab Eng. 2017;Biotechnol J. 2018;ACS Synth Biol. 2019)。JINQI,GAIYANJIUZUJINYIBUJIESHILEGAOXIAOTEYILUOFATATINGSHUIJIEMEIPcESTDECUIHUAJIZHIJIQIJIEGOU-GONGNENGGUANXI,XIANGGUANGONGZUOFABIAOZAIJournal of Biological Chemistry QIKANSHANG。

188体育YANJIURENYUANCHENGGONGJIEXILE4GEGAOFENBIANXSHEXIANJINGTIJIEGOU,BAOKUOPcESTDANTIDANBAI、PcEST-monacolin JFUHEWU、PcESTYUDIWULEISIWUXINFATATINGDEFUHEWUYIJIPcESTSHIHUOTUBIANTIS57AYUDIWULUOFATATINGDEFUHEWU。JIYUJIEGOUFENXI,JIEHETUBIAN、ZHIPUHEITCDENGDUOZHONGSHENGHUAFENXIFANGFA,YANJIURENYUANFAXIAN:Ser-57(QINHESHIJI)-Tyr-170(GUANGYIJIAN)-Lys-60(GUANGYISUAN)CUIHUASANLIANTI、HUOXINGWEIDIANZHOUWEIDEQINGJIANWANGLUOHETEDINGDEDIWUJIEHETONGDAOGONGTONGJUEDINGLEPcESTGAOXIAOTEYIDISHUIJIELUOFATATINGSHENGCHENGmonacolin J,BINGHUIDALEWEISHENMEPcESTNENGGOUGAOXIAOTEYIDISHUIJIELUOFATATINGERBUNENGSHUIJIEXINFATATING。ZAICIJICHUSHANG,YANJIURENYUANJIYUJIEGOUFENXI,JINYIBUDUIPcESTJINXINGLEMEIGONGCHENGGAIZAO,CHENGGONGSHEJIGAIZAOHUODELEKERONGXINGBIAODAHEREWENDINGXINGGAISHANDEPcESTTUBIANTID106A。ZHEIXIEXINGZHIDEGAILIANGYIWEIZHED106ATUBIANTIZAImonacolin JGONGYESHENGCHANZHONGKENENGJUYOUGENGGUANGKUODEYINGYONGQIANJING。

188体育ZHEISHISHOUCIMIAOSHULUOFATATINGSHUIJIEMEICUIHUAJILIHEJIEGOU-GONGNENGGUANXIDEBAODAO,GAIYANJIUCHENGGUOWEIJINYIBUDELUOFATATINGSHUIJIEMEIDESHAIXUAN、MEIGONGCHENGGAIZAOHEGONGYEYINGYONGTIGONGLEJICHUHELILUNZHIDAO。

 

点赞图片

DENGLUHOUCAIKEYIPINGLUN

立即登录
推荐阅读
分享到微信 关闭

DISANFANGDENGLU

请设置您的密码:
请告知您的电话号码,我们将立即回电

188体育TONGHUADUININMIANFEI,QINGFANGXINJIETING

温馨提示:

1.SHOUJIZHIJIESHURU,ZUOJIQIANQINGJIAQUHAO RU18051894089,010-58103778

188体育2.WOMENJIANGGENJUNINTIGONGDEDIANHUAHAOMA,LIJIHUIDIAN,QINGZHUYIJIETING

188体育3.YINWEININSHIBEIJIAOFANG,TONGHUADUININMIANFEI,QINGFANGXINJIETING

关闭
BNCC幸运大抽奖